Rheumatoid arthritis | tnf inhibitors reduce heart attack risk
In the next video I’m going to give you some
interesting findings on rheumatoid arthritis treatment and how it can reduce the chance
of heart attack TNF inhibitors reduce coronary artery disease
risk in rheumatoid arthritis Bianca Nogrady writing in Family Practice
News Network reported the use of tumor necrosis factor–alpha inhibitors was associated with
a significant reduction in the risk of coronary artery disease in patients with rheumatoid
arthritis, particularly with longer term use of the drugs.
The study of 2,101 patients with incident RA diagnosed during 2001-2011 showed that
those treated with a tumor necrosis factor–alpha (TNF-alpha) inhibitor alone or with methotrexate
had 55% lower relative risk of coronary artery disease than did a reference group treated
with non-methotrexate, non-biologic, disease-modifying anti-rheumatic drugs (DMARDs).
Patients treated with methotrexate alone or in combination with other non-biologic DMARDs
showed a non-significant 46% reduction in the incidence of coronary artery disease,
compared with the reference group. The findings were published in Arthritis Care and Research.
Comment: Many studies are now seeing the trend to fewer cardiovascular events in patients
treated with these drugs.